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KMID : 0984920190210010059
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Journal of Skin Barrier Research
2019 Volume.21 No. 1 p.59 ~ p.59
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Vitamin or Its Derivatives and Skin Barriers
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Jang Yong-Hyun
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Abstract
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The skin barrier plays key roles in immune surveillance and homeostasis, and in preventing penetration of microbial products and allergens. Common inflammatory skin disorders such as atopic dermatitis and psoriasis exhibit decreased barrier function, and recent studies suggest that the complex response of epidermal cells to barrier disruption may aggravate, maintain, or even initiate such conditions. Either aiding barrier reestablishment or dampening the epidermal stress response may improve the treatment of these disorders. Nutrition is one of many factors needed for the maintenance of skin homeostasis. Poor nutritional status alters the structural deformation and skin barrier integrity, which in turn leads to an impaired biological function of the skin. The importance of micronutrients (such as certain vitamins and minerals) to skin health has been emphasized in vitro and in vivo. These micronutrients are not only active compounds of treatment to treat certain skin diseases such as atopic dermatitis and psoriasis but are also used as ingredients for
cosmetics. The goal of this review is to discuss the potential roles and current knowledge of selected micronutrients
(vitamin and its derivatives) in skin health and cutaneous barrier function.
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